diff --git a/crypto/cast/cast_s.h b/crypto/cast/cast_s.h
index d9fd6ac416..b27415b967 100644
--- a/crypto/cast/cast_s.h
+++ b/crypto/cast/cast_s.h
@@ -7,7 +7,7 @@
  * https://www.openssl.org/source/license.html
  */
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table0[256] = {
+const CAST_LONG CAST_S_table0[256] = {
     0x30fb40d4, 0x9fa0ff0b, 0x6beccd2f, 0x3f258c7a,
     0x1e213f2f, 0x9c004dd3, 0x6003e540, 0xcf9fc949,
     0xbfd4af27, 0x88bbbdb5, 0xe2034090, 0x98d09675,
@@ -74,7 +74,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table0[256] = {
     0x427b169c, 0x5ac9f049, 0xdd8f0f00, 0x5c8165bf,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table1[256] = {
+const CAST_LONG CAST_S_table1[256] = {
     0x1f201094, 0xef0ba75b, 0x69e3cf7e, 0x393f4380,
     0xfe61cf7a, 0xeec5207a, 0x55889c94, 0x72fc0651,
     0xada7ef79, 0x4e1d7235, 0xd55a63ce, 0xde0436ba,
@@ -141,7 +141,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table1[256] = {
     0x7160a539, 0x73bfbe70, 0x83877605, 0x4523ecf1,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table2[256] = {
+const CAST_LONG CAST_S_table2[256] = {
     0x8defc240, 0x25fa5d9f, 0xeb903dbf, 0xe810c907,
     0x47607fff, 0x369fe44b, 0x8c1fc644, 0xaececa90,
     0xbeb1f9bf, 0xeefbcaea, 0xe8cf1950, 0x51df07ae,
@@ -208,7 +208,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table2[256] = {
     0xdfef4636, 0xa133c501, 0xe9d3531c, 0xee353783,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table3[256] = {
+const CAST_LONG CAST_S_table3[256] = {
     0x9db30420, 0x1fb6e9de, 0xa7be7bef, 0xd273a298,
     0x4a4f7bdb, 0x64ad8c57, 0x85510443, 0xfa020ed1,
     0x7e287aff, 0xe60fb663, 0x095f35a1, 0x79ebf120,
@@ -275,7 +275,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table3[256] = {
     0x13ecf0b0, 0xd3ffb372, 0x3f85c5c1, 0x0aef7ed2,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table4[256] = {
+const CAST_LONG CAST_S_table4[256] = {
     0x7ec90c04, 0x2c6e74b9, 0x9b0e66df, 0xa6337911,
     0xb86a7fff, 0x1dd358f5, 0x44dd9d44, 0x1731167f,
     0x08fbf1fa, 0xe7f511cc, 0xd2051b00, 0x735aba00,
@@ -342,7 +342,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table4[256] = {
     0x5e76ffa8, 0xb1534546, 0x6d47de08, 0xefe9e7d4,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table5[256] = {
+const CAST_LONG CAST_S_table5[256] = {
     0xf6fa8f9d, 0x2cac6ce1, 0x4ca34867, 0xe2337f7c,
     0x95db08e7, 0x016843b4, 0xeced5cbc, 0x325553ac,
     0xbf9f0960, 0xdfa1e2ed, 0x83f0579d, 0x63ed86b9,
@@ -409,7 +409,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table5[256] = {
     0x48392905, 0xa65b1db8, 0x851c97bd, 0xd675cf2f,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table6[256] = {
+const CAST_LONG CAST_S_table6[256] = {
     0x85e04019, 0x332bf567, 0x662dbfff, 0xcfc65693,
     0x2a8d7f6f, 0xab9bc912, 0xde6008a1, 0x2028da1f,
     0x0227bce7, 0x4d642916, 0x18fac300, 0x50f18b82,
@@ -476,7 +476,7 @@ OPENSSL_GLOBAL const CAST_LONG CAST_S_table6[256] = {
     0xf2a279c7, 0x94e01be8, 0x90716f4b, 0x954b8aa3,
 };
 
-OPENSSL_GLOBAL const CAST_LONG CAST_S_table7[256] = {
+const CAST_LONG CAST_S_table7[256] = {
     0xe216300d, 0xbbddfffc, 0xa7ebdabd, 0x35648095,
     0x7789f8b7, 0xe6c1121b, 0x0e241600, 0x052ce8b5,
     0x11a9cfb0, 0xe5952f11, 0xece7990a, 0x9386d174,
diff --git a/crypto/des/spr.h b/crypto/des/spr.h
index 42adfbf6ee..2404e092d4 100644
--- a/crypto/des/spr.h
+++ b/crypto/des/spr.h
@@ -7,7 +7,7 @@
  * https://www.openssl.org/source/license.html
  */
 
-OPENSSL_GLOBAL const DES_LONG DES_SPtrans[8][64] = {
+const DES_LONG DES_SPtrans[8][64] = {
     {
         /* nibble 0 */
         0x02080800L, 0x00080000L, 0x02000002L, 0x02080802L,
diff --git a/include/openssl/asn1t.h b/include/openssl/asn1t.h
index 0a7e3754c3..59b28cf8de 100644
--- a/include/openssl/asn1t.h
+++ b/include/openssl/asn1t.h
@@ -33,7 +33,7 @@ extern "C" {
 /* Macros for start and end of ASN1_ITEM definition */
 
 #  define ASN1_ITEM_start(itname) \
-        OPENSSL_GLOBAL const ASN1_ITEM itname##_it = {
+        const ASN1_ITEM itname##_it = {
 
 #  define static_ASN1_ITEM_start(itname) \
         static const ASN1_ITEM itname##_it = {
diff --git a/include/openssl/e_os2.h b/include/openssl/e_os2.h
index 7812dd4ae2..7960d86f84 100644
--- a/include/openssl/e_os2.h
+++ b/include/openssl/e_os2.h
@@ -147,7 +147,6 @@ extern "C" {
 # endif
 
 /*-
- * OPENSSL_GLOBAL had some meaning for VAX C, which isn't supported any more.
  * OPENSSL_EXTERN is normally used to declare a symbol with possible extra
  * attributes to handle its presence in a shared library.
  * OPENSSL_EXPORT is used to define a symbol with extra possible attributes
@@ -162,18 +161,16 @@ extern "C" {
  * # define OPENSSL_EXTERN OPENSSL_EXPORT
  * #endif
  *
- * The default is to have OPENSSL_EXPORT, OPENSSL_EXTERN and OPENSSL_GLOBAL
+ * The default is to have OPENSSL_EXPORT and OPENSSL_EXTERN
  * have some generally sensible values.
  */
 
 # if defined(OPENSSL_SYS_WINDOWS) && defined(OPENSSL_OPT_WINDLL)
 #  define OPENSSL_EXPORT extern __declspec(dllexport)
 #  define OPENSSL_EXTERN extern __declspec(dllimport)
-#  define OPENSSL_GLOBAL
 # else
 #  define OPENSSL_EXPORT extern
 #  define OPENSSL_EXTERN extern
-#  define OPENSSL_GLOBAL
 # endif
 
 /*-
@@ -194,7 +191,7 @@ extern "C" {
 #  define OPENSSL_DECLARE_GLOBAL(type,name) type *_shadow_##name(void)
 #  define OPENSSL_GLOBAL_REF(name) (*(_shadow_##name()))
 # else
-#  define OPENSSL_IMPLEMENT_GLOBAL(type,name,value) OPENSSL_GLOBAL type _shadow_##name=value;
+#  define OPENSSL_IMPLEMENT_GLOBAL(type,name,value) type _shadow_##name=value;
 #  define OPENSSL_DECLARE_GLOBAL(type,name) OPENSSL_EXPORT type _shadow_##name
 #  define OPENSSL_GLOBAL_REF(name) _shadow_##name
 # endif